IL-15 serves as a co-stimulator in determining the activity of autoreactive CD8 Tcells in an experimental mouse model of graft vs. host like disease

To elucidate the mechanisms controlling peripheral tolerance, we established two transgenic (Tg) mouse strains expressing different levels of membrane-bound ovalbumin (mOVA) as a skin-associated self-antigen. When we transferred autoreactive TCR-Tg CD8 T cells (OT-I cells), keratin14 (K14)-mOVA(high...

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Detalhes bibliográficos
Main Authors: Miyagawa, Fumi, Tagaya, Yutaka, Kim, Brian S, Patel, Hiral J, Ishida, Kazuto, Ohteki, Toshiaki, Waldmann, Thomas A, Katz, Stephen I
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435206/
https://ncbi.nlm.nih.gov/pubmed/18606663
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