Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of IFN-α/β immune defenses that impact cell permissiveness for hepatitis C virus (HCV). Here we evaluated the processes tha...

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Bibliographische Detailangaben
Hauptverfasser: Saito, Takeshi, Hirai, Reiko, Loo, Yueh-Ming, Owen, David, Johnson, Cynthia L., Sinha, Sangita C., Akira, Shizuo, Fujita, Takashi, Gale, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766428/
https://ncbi.nlm.nih.gov/pubmed/17190814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606699104
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