The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane-association and innate antiviral immunity

RIG-I is a cytosolic pathogen recognition receptor that initiates immune responses against RNA viruses. Upon viral RNA recognition, anti-viral signalling requires RIG-I redistribution from the cytosol to membranes where it binds the adaptor protein, MAVS. Here we identify the mitochondrial targeting...

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Main Authors: Liu, Helene Minyi, Loo, Yueh-Ming, Horner, Stacy M., Zornetzer, Gregory A., Katze, Michael G., Gale, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358705/
https://ncbi.nlm.nih.gov/pubmed/22607805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.04.006
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