Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes

The three members of the costimulatory receptor family, CD28, CTLA-4, and ICOS, have complementary effects on T cell activation, and their balance controls the overall outcome of immune and autoimmune responses. They are encoded in a short genomic interval, and overall activity may result from inter...

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Detaylı Bibliyografya
Asıl Yazarlar: Butty, Vincent, Roy, Matt, Sabeti, Pardis, Besse, Whitney, Benoist, Christophe, Mathis, Diane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766426/
https://ncbi.nlm.nih.gov/pubmed/17197413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610124104
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