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Effect of saturable serum protein binding on the pharmacokinetics of unbound cefonicid in humans.

Previous studies have demonstrated high, concentration-dependent serum protein binding of cefonicid. To determine the in vivo pharmacokinetic significance of these observations, the pharmacokinetics of both total and unbound (non-protein-bound) cefonicid was studied in six volunteers after a single...

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Bibliografiske detaljer
Main Authors: Dudley, M N, Shyu, W C, Nightingale, C H, Quintiliani, R
Format: Artigo
Sprog:Inglês
Udgivet: 1986
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC176481/
https://ncbi.nlm.nih.gov/pubmed/3789691
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