Effect of saturable serum protein binding on the pharmacokinetics of unbound cefonicid in humans.

Previous studies have demonstrated high, concentration-dependent serum protein binding of cefonicid. To determine the in vivo pharmacokinetic significance of these observations, the pharmacokinetics of both total and unbound (non-protein-bound) cefonicid was studied in six volunteers after a single...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Dudley, M N, Shyu, W C, Nightingale, C H, Quintiliani, R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176481/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3789691/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.30.4.565
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