Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T...

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Autors principals: Dudley, Mark E., Wunderlich, John R., Robbins, Paul F., Yang, James C., Hwu, Patrick, Schwartzentruber, Douglas J., Topalian, Suzanne L., Sherry, Richard, Restifo, Nicholas P., Hubicki, Amy M., Robinson, Michael R., Raffeld, Mark, Duray, Paul, Seipp, Claudia A., Rogers-Freezer, Linda, Morton, Kathleen E., Mavroukakis, Sharon A., White, Donald E., Rosenberg, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764179/
https://ncbi.nlm.nih.gov/pubmed/12242449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1076514
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