Inability to Immunize Patients with Metastatic Melanoma Using Plasmid DNA Encoding the gp100 Melanoma-Melanocyte Antigen

Immunization with plasmid DNA represents a theoretically attractive method for increasing T cell responses against cancer antigens. We administered plasmid DNA encoding the gp100 melanoma-melanocyte differentiation antigen to 22 patients with metastatic melanoma and evaluated immunologic and clinica...

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Auteurs principaux: Rosenberg, Steven A., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., Restifo, Nicholas P., Haworth, Leah R., Seipp, Claudia A., Freezer, Linda J., Morton, Kathleen E., Mavroukakis, Sharon A., White, Donald E.
Format: Artigo
Langue:Inglês
Publié: 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2078240/
https://ncbi.nlm.nih.gov/pubmed/12804135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/104303403765255110
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