Phase I Study of the Intravenous Administration of Attenuated Salmonella typhimurium to Patients With Metastatic Melanoma

PURPOSE: A strain of Salmonella typhimurium (VNP20009), attenuated by chromosomal deletion of the purI and msbB genes, was found to target to tumor and inhibit tumor growth in mice. These findings led to the present phase I study of the intravenous infusion of VNP20009 to patients with metastatic ca...

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Detalhes bibliográficos
Main Authors: Toso, John F., Gill, Vee J., Hwu, Patrick, Marincola, Francesco M., Restifo, Nicholas P., Schwartzentruber, Douglas J., Sherry, Richard M., Topalian, Suzanne L., Yang, James C., Stock, Frida, Freezer, Linda J., Morton, Kathleen E., Seipp, Claudia, Haworth, Leah, Mavroukakis, Sharon, White, Donald, MacDonald, Susan, Mao, John, Sznol, Mario, Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064865/
https://ncbi.nlm.nih.gov/pubmed/11773163
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