A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma

This report describes a phase I clinical trial using nonmyeloablative, lympho-depleting chemotherapy in combination with adoptive immunotherapy in patients with metastatic melanoma. The chemotherapy-conditioning schedule that induced transient lymphopenia consisted of cyclophosphamide (30 or 60 mg/k...

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Main Authors: Dudley, Mark E., Wunderlich, John R., Yang, James C., Hwu, Patrick, Schwartzentruber, Douglas J., Topalian, Suzanne L., Sherry, Richard M., Marincola, Francesco M., Leitman, Susan F., Seipp, Claudia A., Rogers-Freezer, Linda, Morton, Kathleen E., Nahvi, Azam, Mavroukakis, Sharon A., White, Donald E., Rosenberg, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: 2002
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413438/
https://ncbi.nlm.nih.gov/pubmed/12000866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.CJI.0000016820.36510.89
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