Cilastatin does not alter superoxide dismutase activity.

Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Because zinc stabilizes the mammalian superoxide dismutase, we postulated that cilastatin would also inhibit the dismutase. Cilastatin concentrations at levels threefold higher than those expected in urine, howeve...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Proctor, R A, Textor, J A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3867330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.28.5.691
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