Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.

Unlike mammalian cells, malarial parasites are completely dependent on de novo pyrimidine metabolism. Even though these parasites do not use external uracil or uridine, orotic acid, an intermediate of pyrimidine biosynthesis, is successfully transported into the parasite and incorporated into parasi...

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Podrobná bibliografie

Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Rathod, P K, Khatri, A, Hubbert, T, Milhous, W K
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1989
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2675756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.7.1090
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