Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.

Unlike mammalian cells, malarial parasites are completely dependent on de novo pyrimidine metabolism. Even though these parasites do not use external uracil or uridine, orotic acid, an intermediate of pyrimidine biosynthesis, is successfully transported into the parasite and incorporated into parasi...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Rathod, P K, Khatri, A, Hubbert, T, Milhous, W K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2675756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.7.1090
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