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PPARγ Agonists Prevent TGFβ1/Smad3-Signaling in Human Hepatic Stellate Cells
PPARγ agonists inhibit liver fibrosis, but the mechanisms involved are uncertain. We hypothesized that PPARγ agonists inhibit transforming growth factor (TGF)β1-activation of TGFβ receptor (TGFβR)-1 signaling in quiescent stellate cells, thereby abrogating Smad3-dependent induction of extracellular...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1760476/ https://ncbi.nlm.nih.gov/pubmed/17010940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.09.069 |
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