PPARγ Agonists Prevent TGFβ1/Smad3-Signaling in Human Hepatic Stellate Cells

PPARγ agonists inhibit liver fibrosis, but the mechanisms involved are uncertain. We hypothesized that PPARγ agonists inhibit transforming growth factor (TGF)β1-activation of TGFβ receptor (TGFβR)-1 signaling in quiescent stellate cells, thereby abrogating Smad3-dependent induction of extracellular...

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Bibliografiske detaljer
Main Authors: Zhao, Caiyan, Chen, Wei, Yang, Liu, Chen, Lihong, Stimpson, Stephen A., Diehl, Anna Mae
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1760476/
https://ncbi.nlm.nih.gov/pubmed/17010940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.09.069
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