A mutation in separase causes genome instability and increased susceptibility to epithelial cancer

Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation in the mitotic regulator separase is responsible for the cell cycle defects seen in the zebrafish muta...

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Autori principali: Shepard, Jennifer L., Amatruda, James F., Finkelstein, David, Ziai, James, Finley, K. Rose, Stern, Howard M., Chiang, Ken, Hersey, Candace, Barut, Bruce, Freeman, Jennifer L., Lee, Charles, Glickman, Jonathan N., Kutok, Jeffery L., Aster, Jon C., Zon, Leonard I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2007
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1759900/
https://ncbi.nlm.nih.gov/pubmed/17210788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1470407
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