Synergistic antifungal activity and reduced toxicity of liposomal amphotericin B combined with gramicidin S or NF.

Amphotericin B (AmpB) disrupts membrane integrity by binding to sterols in fungal and mammalian cell membranes. The gramicidins, which form pores in all membranes but exhibit poor antifungal activity, are too toxic to mammalian cells to be used systemically. This study demonstrated synergistic antif...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Hopfer, R L, Mehta, R, Lopez-Berestein, G
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1987
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2449867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.12.1978
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