Synergistic antifungal activity and reduced toxicity of liposomal amphotericin B combined with gramicidin S or NF.
Amphotericin B (AmpB) disrupts membrane integrity by binding to sterols in fungal and mammalian cell membranes. The gramicidins, which form pores in all membranes but exhibit poor antifungal activity, are too toxic to mammalian cells to be used systemically. This study demonstrated synergistic antif...
Zapisane w:
| Wydane w: | Antimicrob Agents Chemother |
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| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Microbiology (ASM)
1987
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2449867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.12.1978 |
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