Synergistic antifungal activity and reduced toxicity of liposomal amphotericin B combined with gramicidin S or NF.

Amphotericin B (AmpB) disrupts membrane integrity by binding to sterols in fungal and mammalian cell membranes. The gramicidins, which form pores in all membranes but exhibit poor antifungal activity, are too toxic to mammalian cells to be used systemically. This study demonstrated synergistic antif...

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Bibliografske podrobnosti

izdano v:	Antimicrob Agents Chemother
Principais autores:	Hopfer, R L, Mehta, R, Lopez-Berestein, G
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1987
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2449867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.12.1978
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