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CpG island methylator phenotype in colorectal cancer

Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG island methylation in colorectal cancer, we have used a recently developed technique called methylated CpG island amplifica...

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Autori principali: Toyota, Minoru, Ahuja, Nita, Ohe-Toyota, Mutsumi, Herman, James G., Baylin, Stephen B., Issa, Jean-Pierre J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC17576/
https://ncbi.nlm.nih.gov/pubmed/10411935
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