An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice
Chronic antagonism of melanocortin receptors by the paracrine-acting agouti gene product induces both yellow fur and a maturity-onset obesity syndrome in mice that ubiquitously express wild-type agouti. Functional analysis of agouti mutations in transgenic mice indicate that the cysteine-rich C term...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
1999
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17559/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411918/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8579 |
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