An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice

Chronic antagonism of melanocortin receptors by the paracrine-acting agouti gene product induces both yellow fur and a maturity-onset obesity syndrome in mice that ubiquitously express wild-type agouti. Functional analysis of agouti mutations in transgenic mice indicate that the cysteine-rich C term...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Miltenberger, R. J., Mynatt, R. L., Bruce, B. D., Wilkison, W. O., Woychik, R. P., Michaud, E. J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1999
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17559/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411918/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8579
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