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Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation

Background: AA amyloidosis develops in patients with chronic inflammatory diseases. The AA amyloid proteins are proteolytic fragments obtained from serum amyloid A (SAA). Previous studies have provided evidence that endosomes or lysosomes might be involved in the processing of SAA, and contribute to...

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Detalhes bibliográficos
Main Authors: Rocken, C, Menard, R, Buhling, F, Vockler, S, Raynes, J, Stix, B, Kruger, S, Roessner, A, Kahne, T
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1755524/
https://ncbi.nlm.nih.gov/pubmed/15897303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2004.030429
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