Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that extracellular acidosis leads to localization of the cysteine pro-tease cathepsin B on the tumor cell membrane and its secretion. The objectiv...

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Detalhes bibliográficos
Main Authors: Rothberg, Jennifer M, Bailey, Kate M, Wojtkowiak, Jonathan W, Ben-Nun, Yael, Bogyo, Matthew, Weber, Ekkehard, Moin, Kamiar, Blum, Galia, Mattingly, Raymond R, Gillies, Robert J, Sloane, Bonnie F
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819629/
https://ncbi.nlm.nih.gov/pubmed/24204192
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