Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that extracellular acidosis leads to localization of the cysteine pro-tease cathepsin B on the tumor cell membrane and its secretion. The objectiv...

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Bibliografiske detaljer
Main Authors: Rothberg, Jennifer M, Bailey, Kate M, Wojtkowiak, Jonathan W, Ben-Nun, Yael, Bogyo, Matthew, Weber, Ekkehard, Moin, Kamiar, Blum, Galia, Mattingly, Raymond R, Gillies, Robert J, Sloane, Bonnie F
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819629/
https://ncbi.nlm.nih.gov/pubmed/24204192
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