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Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin
Background: The anti-tumour antibiotic mithramycin is also a potent inhibitor of fibrosis after glaucoma surgery. This drug displays high affinity binding to GC-rich sequences in DNA, including those present in the promoter of the gene encoding the α1 chain of type I collagen (COL1A1). Objective: To...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1755322/ https://ncbi.nlm.nih.gov/pubmed/15901633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2005.037515 |
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