Safety and immunogenicity in humans of an attenuated Salmonella typhi vaccine vector strain expressing plasmid-encoded hepatitis B antigens stabilized by the Asd-balanced lethal vector system.

Attenuated Salmonella typhi organisms which express genes encoding protective antigens of other pathogens have been developed for use as experimental oral vaccines. A delta asd S. typhi strain attenuated by deletions in cya, crp, and cdt which contains hepatitis B core (HBc) and pre-S genes encoded...

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Publié dans:	Infect Immun
Auteurs principaux:	Tacket, C O, Kelly, S M, Schödel, F, Losonsky, G, Nataro, J P, Edelman, R, Levine, M M, Curtiss, R
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175478/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.8.3381-3385.1997
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