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Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis
Background: Leflunomide and its active metabolite A77 1726 reversibly inhibits the enzyme dihydro-orotate dehydrogenase, the rate limiting step in de novo synthesis of pyrimidines and progression of the cell cycle in different cell lines, mainly activated T lymphocytes. Objective: To analyse in vitr...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1754507/ https://ncbi.nlm.nih.gov/pubmed/12634225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.62.4.297 |
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