CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production

INTRODUCTION: Co-stimulatory signal B7(CD80/CD86):CD28 is needed in order to activate T cells in immune response. Cytotoxic T lymphocyte-associated antigen-4-immunoglobulin (CTLA4-Ig) binding to the B7 molecules on antigen-presenting cells downregulates this activation and represents a recent biolog...

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Main Authors: Cutolo, Maurizio, Soldano, Stefano, Montagna, Paola, Sulli, Alberto, Seriolo, Bruno, Villaggio, Barbara, Triolo, Pierfranco, Clerico, Paolo, Felli, Lamberto, Brizzolara, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003520/
https://ncbi.nlm.nih.gov/pubmed/19930661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2865
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