Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay

BACKGROUND: Systemic sclerosis (SSc) is characterized by vasculopathy and progressive fibrosis. CTLA4-Ig (abatacept) is able to interact with the cell surface costimulatory molecule CD86 and downregulate the target cell. The aim of this study was to evaluate the in-vitro effects of CTLA4-Ig treatmen...

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Bibliografiska uppgifter
I publikationen:Arthritis Res Ther
Huvudupphovsmän: Cutolo, Maurizio, Soldano, Stefano, Montagna, Paola, Trombetta, Amelia Chiara, Contini, Paola, Ruaro, Barbara, Sulli, Alberto, Scabini, Stefano, Stratta, Emanuela, Paolino, Sabrina, Pizzorni, Carmen, Smith, Vanessa, Brizzolara, Renata
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062881/
https://ncbi.nlm.nih.gov/pubmed/30053831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1652-6
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