Hot-spot mutants of p53 core domain evince characteristic local structural changes

Most of the oncogenic mutations in the tumor suppressor p53 map to its DNA-binding (core) domain. It is thus a potential target in cancer therapy for rescue by drugs. To begin to understand how mutation inactivates p53 and hence to provide a structural basis for drug design, we have compared structu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wong, Kam-Bo, DeDecker, Brian S., Freund, Stefan M. V., Proctor, Mark R., Bycroft, Mark, Fersht, Alan R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10411893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.15.8438
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