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Correlation between in vitro and in vivo concentration–effect relationships of naproxen in rats and healthy volunteers
1. Understanding the mechanisms underlying the analgesic effect of new cyclooxygenase inhibitors is essential to identify dosing requirements in early stages of drug development. Accurate extrapolation to humans of in vitro and in vivo findings in preclinical species is needed to optimise dosing reg...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1751780/ https://ncbi.nlm.nih.gov/pubmed/16682968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706737 |
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