Evidence that the plant cannabinoid Δ(9)-tetrahydrocannabivarin is a cannabinoid CB(1) and CB(2) receptor antagonist

1. Δ(9)-tetrahydrocannabivarin (THCV) displaced [(3)H]CP55940 from specific binding sites on mouse brain and CHO-hCB(2) cell membranes (K(i)=75.4 and 62.8 nM, respectively). 2. THCV (1 μM) also antagonized CP55940-induced stimulation of [(35)S]GTPγS binding to these membranes (apparent K(B)=93.1 and...

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Autores principales: Thomas, Adèle, Stevenson, Lesley A, Wease, Kerrie N, Price, Martin R, Baillie, Gemma, Ross, Ruth A, Pertwee, Roger G
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751228/
https://ncbi.nlm.nih.gov/pubmed/16205722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706414
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