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Determination of solvent content in cavities in IL-1β using experimentally phased electron density

The extent to which water is present within apolar cavities in proteins remains unclear. In the case of interleukin-1β (IL-1β), four independent structures solved by x-ray crystallography indicate that water is not present in the central apolar cavity. In contrast, results from NMR spectroscopy sugg...

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Detalhes bibliográficos
Main Authors: Quillin, Michael L., Wingfield, Paul T., Matthews, Brian W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1750907/
https://ncbi.nlm.nih.gov/pubmed/17179045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609442104
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