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Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation

Formation of a water-expelling nonpolar core is the paradigm of protein folding and stability. Although experiment largely confirms this picture, water buried in “hydrophobic” cavities is required for the function of some proteins. Hydration of the protein core has also been suggested as the mechani...

詳細記述

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書誌詳細
主要な著者: Collins, Marcus D., Hummer, Gerhard, Quillin, Michael L., Matthews, Brian W., Gruner, Sol M.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283839/
https://ncbi.nlm.nih.gov/pubmed/16269539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508224102
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