Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.

LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold h...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Dong, M Y, Chang, T W, Gorbach, S L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2821892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.7.1135
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