Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.
LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold h...
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| Izdano u: | Antimicrob Agents Chemother |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
1987
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2821892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.7.1135 |
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