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Viral protease cleavage of inhibitor of κBα triggers host cell apoptosis

Apoptosis is an innate immune response to viral infection that limits viral replication. However, the mechanisms by which cells detect viral infection and activate apoptosis are not completely understood. We now show that during Coxsackievirus infection, the viral protease 3C(pro) cleaves inhibitor...

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Autores principales: Zaragoza, Carlos, Saura, Marta, Padalko, Elizaveta Y., Lopez-Rivera, Ester, Lizarbe, Tania R., Lamas, Santiago, Lowenstein, Charles J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748175/
https://ncbi.nlm.nih.gov/pubmed/17138672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606019103
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