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Enzyme-triggered Gelation: Targeting Proteases with Internal Cleavage Sites

A generalizable method for detecting protease activity via gelation is described. A recognition sequence is used to target the protease of interest while a second protease is used to remove the residual residues from the gelator scaffold. Using this approach, selective assays for both MMP-9 and PSA...

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Hlavní autoři: Bremmer, Steven C., McNeil, Anne J., Soellner, Matthew B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143987/
https://ncbi.nlm.nih.gov/pubmed/24394494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc48132h
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