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Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor

Epidermal growth factor receptor (EGFR) at membrane microdomains plays an essential role in the growth control of epidermal cells, including cancer cells derived therefrom. Ligand-dependent activation of EGFR tyrosine kinase is known to be inhibited by ganglioside GM3, but to a much lesser degree by...

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Autores principales: Yoon, Seon-Joo, Nakayama, Ken-ichi, Hikita, Toshiyuki, Handa, Kazuko, Hakomori, Sen-itiroh
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748164/
https://ncbi.nlm.nih.gov/pubmed/17142315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609281103
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