Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma

Background: LTC4 synthase is essential for the production of cysteinyl leukotrienes (Cys-LT), critical mediators in asthma. We have identified a novel promoter polymorphism at position -1072 (G/A) and a -444 (A/C) polymorphism has previously been reported. The role of these polymorphisms in the gene...

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Main Authors: Sayers, I, Barton, S, Rorke, S, Beghe, B, Hayward, B, Van Eerdewegh, P, Keith, T, Clough, J, Ye, S, Holloway, J, Sampson, A, Holgate, S
Format: Artigo
Language:Inglês
Published: BMJ Group 2003
Subjects:
Asthma
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1746660/
https://ncbi.nlm.nih.gov/pubmed/12728163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thorax.58.5.417
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