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Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor

Background: Smooth muscle contraction is one of the hallmarks of asthma. A recently developed pyridine derivative, Y-27632, a selective Rho kinase inhibitor, has been reported to inhibit the smooth muscle contraction of human and animal trachea in ex vivo systems but its effect in animal models of a...

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Главные авторы: Hashimoto, K, Peebles, R, Sheller, J, Jarzecka, K, Furlong, J, Mitchell, D, Hartert, T, Graham, B
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Group 2002
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1746359/
https://ncbi.nlm.nih.gov/pubmed/12037228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thorax.57.6.524
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