Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.

Heat-labile toxin (LT) is a protein related to cholera toxin, produced by enterotoxigenic Escherichia coli strains, that is organized as an AB5 complex. A number of nontoxic derivatives of LT, useful for new or improved vaccines against diarrheal diseases or as mucosal adjuvants, have been construct...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Magagnoli, C, Manetti, R, Fontana, M R, Giannelli, V, Giuliani, M M, Rappuoli, R, Pizza, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174546/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8945604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.12.5434-5438.1996
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