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Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.

Heat-labile toxin (LT) is a protein related to cholera toxin, produced by enterotoxigenic Escherichia coli strains, that is organized as an AB5 complex. A number of nontoxic derivatives of LT, useful for new or improved vaccines against diarrheal diseases or as mucosal adjuvants, have been construct...

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Main Authors: Magagnoli, C, Manetti, R, Fontana, M R, Giannelli, V, Giuliani, M M, Rappuoli, R, Pizza, M
格式: Artigo
語言:Inglês
出版: 1996
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC174546/
https://ncbi.nlm.nih.gov/pubmed/8945604
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