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Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity.

Helicobacter pylori, an etiologic agent of gastritis and peptic ulceration in humans, synthesizes urease, a nickel metalloenzyme, as its most abundant protein. NixA, a high-affinity nickel transport protein, allows synthesis of catalytically active urease when coexpressed with H. pylori urease in an...

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Bibliographic Details
Main Authors: Bauerfeind, P, Garner, R M, Mobley, L T
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC174160/
https://ncbi.nlm.nih.gov/pubmed/8698529
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