Melanocortin-1 receptor gene variants affect pain and µ-opioid analgesia in mice and humans

Background: A recent genetic study in mice and humans revealed the modulatory effect of MC1R (melanocortin-1 receptor) gene variants on κ-opioid receptor mediated analgesia. It is unclear whether this gene affects basal pain sensitivity or the efficacy of analgesics acting at the more clinically rel...

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Detalhes bibliográficos
Main Authors: Mogil, J, Ritchie, J, Smith, S, Strasburg, K, Kaplan, L, Wallace, M, Romberg, R, Bijl, H, Sarton, E, Fillingim, R, Dahan, A
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2005
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1736101/
https://ncbi.nlm.nih.gov/pubmed/15994880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.027698
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