The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated in rodents, and these qualitative sex differences appear to be relevant to analgesia from κ-opioid receptor agonists, a drug class reported to be clinically effective only in women. Via quantitative trait l...

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Hauptverfasser: Mogil, Jeffrey S., Wilson, Sonya G., Chesler, Elissa J., Rankin, Andrew L., Nemmani, Kumar V. S., Lariviere, William R., Groce, M. Kristina, Wallace, Margaret R., Kaplan, Lee, Staud, Roland, Ness, Timothy J., Glover, Toni L., Stankova, Magda, Mayorov, Alexander, Hruby, Victor J., Grisel, Judith E., Fillingim, Roger B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153647/
https://ncbi.nlm.nih.gov/pubmed/12663858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0730053100
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