The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated in rodents, and these qualitative sex differences appear to be relevant to analgesia from κ-opioid receptor agonists, a drug class reported to be clinically effective only in women. Via quantitative trait l...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Mogil, Jeffrey S., Wilson, Sonya G., Chesler, Elissa J., Rankin, Andrew L., Nemmani, Kumar V. S., Lariviere, William R., Groce, M. Kristina, Wallace, Margaret R., Kaplan, Lee, Staud, Roland, Ness, Timothy J., Glover, Toni L., Stankova, Magda, Mayorov, Alexander, Hruby, Victor J., Grisel, Judith E., Fillingim, Roger B.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2003
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153647/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663858/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0730053100
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