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Reappraisal of the historical selective pressures for the CCR5-Δ32 mutation
HIV strains are unable to enter macrophages that carry the CCR5-Δ32 deletion; the average frequency of this allele is 10% in European populations. A mathematical model based on the changing demography of Europe from 1000 to 1800 AD demonstrates how plague epidemics, 1347 to 1670, could have provided...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BMJ Group
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1736018/ https://ncbi.nlm.nih.gov/pubmed/15744032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.025346 |
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