The p53 codon 72 variation is associated with the age of onset of hereditary non-polyposis colorectal cancer (HNPCC)

The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant. From the evidence that the DNA mismatch repair system and p53 interact to maintain genomic integ...

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Bibliographische Detailangaben
Hauptverfasser: Kruger, S, Bier, A, Engel, C, Mangold, E, Pagenstecher, C, von Knebel, Doeber... M, Holinski-Feder, E, Moeslein, G, Schulmann, K, Plaschke, J, Ruschoff, J, Schackert, H, the, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Group 2005
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735929/
https://ncbi.nlm.nih.gov/pubmed/16199549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.028506
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