The p53 codon 72 variation is associated with the age of onset of hereditary non-polyposis colorectal cancer (HNPCC)

The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant. From the evidence that the DNA mismatch repair system and p53 interact to maintain genomic integ...

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Detalhes bibliográficos
Main Authors: Kruger, S, Bier, A, Engel, C, Mangold, E, Pagenstecher, C, von Knebel, Doeber... M, Holinski-Feder, E, Moeslein, G, Schulmann, K, Plaschke, J, Ruschoff, J, Schackert, H, the, G
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2005
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735929/
https://ncbi.nlm.nih.gov/pubmed/16199549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2004.028506
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