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Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome

Methods: Out of 15 HNPCC or HNPCC-like patients who developed tumours with loss of hMSH6 protein expression, we selected three patients who still had no germline mutations after gene sequencing. Genomic DNA of these patients was analysed using PCR based relative quantification of hMSH6 fragments. In...

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書誌詳細
主要な著者: Plaschke, J, Ruschoff, J, Schackert, H
フォーマット: Artigo
言語:Inglês
出版事項: BMJ Group 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735570/
https://ncbi.nlm.nih.gov/pubmed/12920072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.40.8.597
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